Prof. Nader Sheibani
Position title: Vascular MAPs Principal Investigator
Phone: (608) 263-3345
Wisconsin Institute for Medical Research
1111 Highland Ave
Madison WI 53705
Our laboratory studies the molecular and cellular mechanisms that regulate angiogenesis. We are interested in how alterations in normal regulatory mechanisms, under pathological conditions such as ischemia and diabetes, leads to vascular abnormalities and neovascularization. We use the postnatal developing retinal vasculature as a model to study all aspects of vascular development. In addition, we have established a number of mouse models to study neovascularization associated with aging, ischemia and diabetes. Our in vivo studies are complemented with our unique ability to culture retinal vascular cells from wild type and transgenic mice for in vitro studies. The utilization of these models has provided novel insight into the role of a number of genes in regulation of retinal vascular development and neovascularization. We are also utilizing our vascular cells for development of cell-based assays for identification of small molecules with potential therapeutic benefit for various eye diseases with a neovascular component.